한양대학교 약학대학 하정미교수|Hanyang University Professor

1. 01 “Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer's Disease: In Vivo Studies on Mouse Models” Joonhong Jun, Hyungwoo Moon, Songyi Yang et al Jung-Mi Hah Journal of Medicinal Chemistry 2023, 66 (9), 6372-6390.
2. 02 “Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases” JoonhongJun, Jihyun Baek et al Jung-Mi Hah   European Journal of Medicinal Chemistry 2023, 245 (1), 114917-114931.
3. 03 “Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease” Joonhong Jun, Songyi Yang et al Jung-Mi Hah European Journal of Medicinal Chemistry 2023, 245 (1), 114894-114913.
4. 04 “Design of Novel IRAK4 Inhibitors Using Molecular Docking, Dynamics Simulation and 3D-QSAR Studies” Swapnil P.Bhuzbal, Weijie He, Jung-Mi Hah  Molecules  2022, 27, 6307-6320. 
5. 05 “Design and Synthesis of Aminopyrimidinyl Pyrazole Analogs as PLK1 Inhibitors Using Hybrid 3D-QSAR and Molecular Docking” Swapnil P.Bhuzbal, Hyejin Kim, Hyunah Bae, Jung-Mi Hah  Pharmaceuticals  2022, 15, 1170-1184.
6. 06 “Rational design and synthesis of 2-(1H-indazol-6- yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants” Daseul Im, Joonhong Jun, Jihyun Baek,  Hyejin Kim, Dahyun Kang, Hyunah Bae,  Hyunwook Cho, Jung-Mi Hah  Journal of Enzyme inhibition and  Med. Chem.  2022, 37(1), 472-486.
7. 07 “Generation of Non-Nucleotide CD73 Inhibitors Using a Molecular Docking and 3D-QSAR Approachr” Swapnil P.Bhuzbal, Jung-Mi Hah  International Journal of Molecular Science   2021, 22(23), 12745-12757.
8. 08 “Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid beta-Induced Neurotoxicity in Primary Rat Neurons” Joonhong Jun, Jihyun Baek, Songyi Yang, Hyungwoo Moon, Hyejin Kim, Hyunwook Cho, Jung-Mi Hah   International Journal of Molecular Science 2021, 22(20), 11084-11101.
9. 09 “A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer's Disease: Investigating Structure through Docking Studies” Hyunwook Cho, Jung-Mi Hah   Biomedicine 2021, 9(10), 1431-1443.
10. 10 “Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model” Youri Oh, Hoyong Jung, Hyejin Kim, Jihyun Baek, Joonhong Jun, Hyunwook Cho, Daseul Im, Jung-Mi Hah International Journal of Molecular Science 2021, 22(8), 3865-3879.
11. 11 “Discovery of 5-methyl-N-(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors” Daseul Im, Jinwoong Kim, Hyungwoo Moon,Youri Oh, Miyoung Jang, Jung-Mi Hah  Journal of Enzyme inhibition and  Med. Chem.  2020, 35, 1110-1115.
12. 12 “Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1H)-Carboxamide as a Novel JNK Inhibitor” Miyoung Jang, Jinwoong Kim, Daseul Im, Hoyong Jung, Hyungwoo Moon, Waqar Aman, Jung-Mi Hah  International Journal of Molecular Science   2020, 21, 1698-1714.
13. 13 “Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives as a novel selective inhibitor scaffold of JNK3” Youri Oh, Miyoung Jang, Songyi Yang, Hyungwoo Moon, Hyunwook Cho, Daseul Im, Jung-Mi Hah Journal of Enzyme inhibition and Med. Chem.  2020, 35, 372-376.
14. 14 “Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl-N-(2-aryl-1H-benzo[d]imidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors” Daseul Im, Jinwoong Kim, Hyungwoo Moon, Youri Oh, Miyoung Jang, Jung-Mi Hah  Journal of Enzyme inhibition and  Med. Chem. 2019, 34, 1716-1721.
15. 15 “Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as a highly selective and potent BRAFV600E and CRAF inhibitor” Jinwoong Kim, Daseul Im, Hoyong Jung, Hyungwoo Moon, Waqar Aman, Jung-Mi Hah Journal of Enzyme inhibition and Med. Chem. 2019, 34, 1314-1320.
16. 16 “Chemistry-oriented synthesis (ChOS) and target deconvolution on neuroprotective effect of a novel scaffold, oxaza spiroquinone” Arramshetti Venkanna,, Kyo Hee Cho, Lama Prema Dhorma, Duddukuri Nandan Kumar, Jung Mi Hah, Hyeung-geun Park, Sun Yeou Kim, Mi-hyun Kim  European Journal of Medicinal Chemistry 2019, 163, 453-480.
17. 17 “Design, synthesis, and in vitro evaluation of N-(3-(3-alkyl-1H-pyrazol-5-yl) phenyl)-aryl amide for selective RAF inhibition” Hoyong Jung, Jinwoong Kim, Daseul Im, Hyungwoo Moon, Jung-Mi Hah Bioorg. Med. Chem. Lett. 2019, 29 534-538.
18. 18 "Discovery of novel 4-aryl-thieno[1,4] diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents” Junghun Lee, Hoyong Jung, Minjung Kim, Eunkyu Lee, Daseul Im, Waqar Aman, Jung-Mi Hah Bioorg. Med. Chem. 2018, 26, 1628-1637.
19. 19 “Novel scaffold evolution through combinatorial 3D-QSAR model studies of two types of JNK3 inhibitors” Hoyong Jung, Waqar Aman, Jung-Mi Hah Bioorg. Med. Chem. Lett. 2017, 27 2139-2143.
20. 20 “Nec-1 alleviates cognitive impairment with reduction of A and tau abnormalities in APP/PS1 mice” Seung-Hoon Yang, Dongkeun Kenneth Lee, Jisu Shin, Sejin Lee, Seungyeop Baek, Jiyoon Kim, Hoyong Jung, Jung-Mi Hah & Young Soo Kim, EMBO Mole. Med. 2017, 9 (1), 61-77
21. 21 “Discovery of highly selective CRAF inhibitors, 3-carboxamido-2H-indazole-6-arylamide: In silico FBLD design, synthesis and evaluation” Waqar Aman, Junghun Lee, Minjung Kim, Songyi Yang, Hoyong Jung, Jung-Mi Hah Bioorg. Med. Chem. Lett. 2016, 26, 1188-1192
22. 22 "Synthesis of stereochemically diverse cyclic analogs of tubulysins” Yunjeong Park, Song Yi Bae, Jung-Mi Hah, Sang Kook Lee, Jae-Sang Ryu Bioorg. Med. Chem. 2015, 23, 6827-6843.
23. 23 “Discovery of 4-arylamido 3-methyl isoxazole derivatives as novel FMS kinase inhibitors” Daseul Im, Kyungjin Jung, Songyi Yang, Waqar Aman, Jung-mi Hah European Journal of Medicinal Chemistry 2015, 102, 600-610.
24. 24 “De Novo Design and Synthesis of a y-Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand” Mi-Hyun Kim, Junghun Lee, , Jung-Hah Chemistry An Asian Journal 2015, 10,1318-1326.
25. 25 “Click approach to the discovery of 1,2,3-triazolylsalicylamides as potent Aurora kinase inhibitors” Bioorg. Med. Chem. 2014, 24 (17), 4855-4866
26. 26 “Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl)pyrimidine analogues as selective and potent Raf inhibitors” Bioorg. Med. Chem. Lett. 2014, 24, 3600-3604.
27. 27 “Syntheses and biological evaluation of 1-heteroaryl-2aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects” Mi-Hyun Kim, Junghun Lee, Kyungjin Jung, Minjung Kim, Yunjin Park, Hee-Chul Ahn, Younghye Kwon, Jung-mi Hah Bioorg. Med. Chem. 2013, 21 (22), 2271-2285.
28. 28 “Synthesis and biological evaluation of 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles as transforming growth factor-beta type 1 receptor Idnase inhibitors” Fei Li, Yunjeong Park, Jung-Mi Hah, Jae-Sang Ryu Bioorg. Med. Chem. Lett. 2013, 23, 1083-1086.
29. 29 “3D-QSAR studies of 1,2-diaryl-1H-benzimidazole derivatives as JNK3 inhibitors with protective effects in neuronal cells” Bioorg. Med. Chem. Lett. 2013, 23, 1639-1642.
30. 30 “In silico binding free energy predictability with p-p interaction energy-augmented scoring function: Benzimidazole Raf inhibitors as a case study” Jae Yoon Chung, Seung Joo Cho, Art E, Cho, Jung-Mi Hah Bioorg. Med. Chem. Lett. 2012, 22, 3278-3283.
31. 31 “New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line” Hee Jin Kim, Hye Jung Cho, Hwan Kim, Mohammed I. EI-Gamal, Chang-Hyun Oh, So Ha Lee, Taebo Sim, Jung-Mi Hah, Kyung Ho Yoo Bioorg. Med. Chem. Lett. 2012, 22, 3269-3273.
32. 32 “Rhodium-catalyzed reductive cyclization of 1,6-enynes and stereoselective synthesis of the putative structure of lucentamycin A and its stereoiso4mers” Young Jin Ham, Hana Yu, Nam Doo Kim, Jung-mi Hah, Khalid B. Selim a, Hwan Geun Choi, Taebo Sim Tetrahedron 2012, 19, 1918-1925.
33. 33 “Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells” Hyangmi Kim, Minjung Kim, Hana Yu, Junghun Lee Jung-Mi Hah Bioorg. Med. Chem. 2011, 19 (22), 6760-6767.
34. 34 “A python-based docking program utilizing a receptor bound ligand shape: PythDock” Jae Yoon Chung, Seung Joo Cho, Jung-mi Hah Archiv. Pharm. Res. 2011, 34 (9), 1451-1458.
35. 35 “Structure tuning of pyrazolylpyrrole derivatives as ERK inhibitors dual tools; 3D-QSAR and side chain hopping” MI-hyun Kim, Jae Yoon Chung, Jae-Sang Ryu, Jung-Mi Hah Bioorg. Med. Chem. Lett. 2011, 21, 4900-4904
36. 36 “Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells” Mi-hyun Kim, Minjung Kim, Hana yu, Hwan Kim, Kyung Ho Yoo, Taebo Sim, Jung-Mi Hah Bioorg. Med. Chem. 2011, 19, 1915-23.
37. 37 “Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines Against Melanoma Cell Line” Hyemi Ahn, Jun A Lee, Hwan Kim, Chang-Hyun Oh, So Ha Lee, Taebo Sim, Jung-Mi Hah, Dong Jin Kim, and Kyung Ho Yoo Bull. Korean Chem. Soc 2011, 32, 1209~14
38. 38 “Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line” Lee, Junsang; Nam, Bong Soo; kim, Hwan; Oh, Chang-Hyun; Lee, So Ha; Cho, Seung Joo, Sim, Taebo; Hah, Jung-Mi; Kim, Dong Jin; Tae, Jinsung Bioorg. Med. Chem. Lett. 2010, 20, 5722-5725.
39. 39 “An efficient and enantioselective total synthesis of naturally occurring L-783277” Choi, Hwan Geun; Son, Jung Beom; Park, Dong-Sik; Ham, Young Jin; Hah, Jung-Mi; Sim, Taebo Tetrahedron Letters 2010, 51(38), 4942-4946.
40. 40 “The efficient one-step chlorination of methylsulfanyl group on pyrimidine ring system with sulfuryl chloride” Ham, Young Jin; Lee, Duck-Hyung; Choi, Hwan Geun; Hah, Jung-Mi; Sim, Taebo Tetrahedron Letters 2010, 51(35), 4609-4611.
41. 41 “1,4-Dihydropyrazolo[4,3-d]imidazole phenyl derivatives : A Novel Type Ⅱ Raf kinase inhibitors” Hana Yu, Yunkyung Jung, Hwan Kim, Junghun Lee, Chang-Hyun Oh, Kyung Ho Yoo, Taebo Sim and Jung-Mi Hah Bioorg. Med. Chem. Lett. 2010, 20, 3805-3808.
42. 42 “QM/MM based 3D QSAR models for potent B Raf inhibitors “Jae Yoon Chung, Hwan Won Chung, Seung Joo Cho, Art E. Cho, Jung-Mi Hah J. Computer-Aided Molecular Design 2010, 24, 385-397.
43. 43 “Discovery and Initial SAR of Pyrimidin-4-yl-1H-imidazole derivatives with Antiproliferative activity against Melanoma cell lines” Junghun Lee, Hwan Kim, Hana Yu, Jae Yoon Chung, Chang-Hyun Oh, Kyung Ho Yoo, Taebo Sim, and Jung-Mi Hah Bioorg. Med. Chem. Lett. 2010, 20, 1573-1577.
44. 44 “Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanoma” Hee-Jin Kim, Myung-Ho Jung, Hwan Kim, Mohammed I, El-Gamal, So Ha Lee, Kyung Ho Yoo, Tae Bo Sim, Jung-Mi Hah, Jung-Hyuck Cho, Jung Hoon Choi, Chang-Hyun Oh Bioorg. Med. Chem. Lett. 2009, 20, 413-417.
45. 45 “Correlation between Performance of QM/MM Docking and Simple Classification of Binding Sites” Jae Yoon Chung, Art E Cho, Jung-Mi Hah” J. Chem. Inf. Model. 2009, 49, 2382~2387.
46. 46 “Hologram and Receptor-Guided 3D QSAR Analysis of Anilinopyridine JNK3 Inhibitors” Jae Yoon Chung, Art E Cho, Jung-Mi Hah” Bull. Kor. Chem. Soc. 2009, 30, 2739~2748.
47. 47 “Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line” Myung-Ho Jung, Hwan Kim, Won-Kyung Choi, Mohammed I. El-Gamal, Jin-Hun Park, , So Ha Lee, Kyung Ho Yoo, Tae Bo Sim, Jung-mi Hah, Jung-Hyuck cho, Jung Hoon Choi, Chang-Hyun Oh Bioorg. Med. Chem. Lett. 2009, 19, 6538~6543.
48. 48 “Aminoquinoline Derivatives with Antiproliferative Activity Against Melanoma Cell Line” Bong Soo Nam, Hwan Kim, Chang-Hyun Oh, So Ha Lee, Seung Joo Cho, Tae Bo Sim, Jung-Mi Hah, Dong Jin Kim, Jung Hoon choi, Kyung Ho Yoo Bioorg. Med. Chem. Lett. 2009, 19, 3517~3520.
49. 49 “Pharmacophore based 3D-QSAR study of VEGFR-2 inhibitors” M. M. Neaz, F. A. Pasha, M. Muddassar, So Ha Lee, Taebo Sim, Jung-Mi Hah, Seung Joo Cho Med. Chem. Res. 2009, 18, 127~142
50. 50 “Light-Mediated Liberation of Enzymatic Activity: “Small Molecule” Caged Protein Equivalents”Haishan Li, Jung-Mi Hah and David S. Lawrence. J. Am. Chem. Soc. 2008, 130, 10474~10475
51. 51 “Acquisition of Selective Src Kinase Inhibitor via a Global Targeting Strategy” Jung-Mi Hah Drugs of the Future 2007, 32, 25 ~26
52. 52 "Acquisition of a Group A-selective Src Kinase Inhibitor via a Global Targeting Strategy" Jung-Mi Hah, Vyas Sharma, Haishan Li and David S. Lawrence. J. Am. Chem. Soc. 2006, 128, 5996 ~5997
53. 53 “Structural Basis for Dipeptide Amide Isoform-Selective Inhibition of Neuronal Nitric Oxide Synthase” Flinspach, M.; Li, H.; Jamal, J.; Yang, W.; Huang, H.; Jung-Mi Hah; Gomez-Vidal, J. A.; Litzinger, E. A.; Silverman, R. B.; Poulos, T. L. Nature (Structural Biology) 2004, 11, 54-59.
54. 54 “Aromatic, Reduced Amide Bond Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase” Jung-Mi Hah, Linda J. Roman, Pavel Martasek and Richard B. Silverman J. Med. Chem. 2003, 46, 1661-1669.
55. 55 “Reduced Amide Bond Peptidomimetics. (4S)-N(4-Amino-5-[aminoalkyl]aminopentyl)-N’ -nitroguanidines, Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase” Jung-Mi Hah, Linda J. Roman, Pavel Martasek and Richard B. Silverman J. Med. Chem. 2001, 44, 2667-2670.
56. 56 “Mechanism of Nitric Oxide Synthase. Evidence that Direct Hydrogen Atom Abstraction from the O-H Bond of NG-Hydroxyarginine Is Not Relevant to the Mechanism” Hui Huang, Jung-Mi Hah and Richard B. Silverman J. Am. Chem. Soc. 2001, 123, 2674-2676.
57. 57“Deuterium Isotope Effects and product Studies for the Oxidation of Nw-Allyl-L-arginine and Nw-Allyl-Nw-hydroxy-L-arginine by Neuronal Nitric Oxide Synthase” Jung-Mi Hah, Linda J. Roman and Richard B. Silverman Bioorg. Med. Chem. 2000, 8, 1931-1936.
58. 58 “Enantioselective synthesis of 20(S)-camptothecin using Sharpless catalytic asymmetric dihydroxylation” Sang-sup Jew, Kwang-Dae Ok, Hee-Jin Kim, Myung-Gu Kim, Jong-Min Kim, Jung-Mi Hah, and Yoon-Sang Cho Tetrahedron: Asymmetry 1995, 6, 1245-1248.

Honors and Activities

• The Best Teacher Award, 2015 Hanyang University
• The Best Teacher Award, 2014 Hanyang University
• The best graduate Poster Award in DDP symposium, Northwestern University, Chicago, Il (2001)
• Excellent Graduate Fellowship, Seoul National University (1994-1996)
• SNU Alumni Scholarship, Seoul National University (1991-1994)
• Graduated Summa Cum Laude from Department of Manufacturing Pharmacy,
• Seoul National University (1994)
• Honor scholarship, Seoul National University (1990)